It’s World Statistics Day! To honor the theme of the day, the JMP User Community is having conversations about the importance of trust in statistics and data. And we want to hear from you! Tell us the steps you take to ensure that your data is trustworthy.
Choose Language Hide Translation Bar
Highlighted
Level I

## How do I create a model with a defined profile as a factor?

Hi all,

I have a question regarding DoE design.

Normally, I use continuous factors with fixed values for 0, -1, +1, with the custom design DoE. However, I now have to create a model for a cell culture process (duration is multiple days), where one of the input factors has a profile at the lower range (the other factors will be fixed values for 0, -1, +1). Can someone explain to me how I can design this model?

further more, what would be preferred, from a statistical point of view:

1) keep upper range fixed and centerpoint fixed, so only profile for lower range

or

2) have same shape profile for upper range and centerpoint as used for -1

I have plotted scenenario 1 and 2 in the attached file as I cannot add the pictures in this message.

any help is very welcome, I very much look forward to your response/ideas

kind regards,

Marjolein

1 ACCEPTED SOLUTION

Accepted Solutions
Highlighted
Level II

## Re: How do I create a model with a defined profile as a factor?

Hi Marjolein,

yes, the categorical factor wouldn't follow a profile, but it doesn't have to. Just create a categorical factor with three levels:

 Factor Name Role Values X Categorical L1 = profile 1 L2 = profile 2 L3 = profile 3

The profiles don't have to be the same, each can follow an unique time-program. The "mid-level" (profile 2) doesn't have to be the "center-point" as you showed in your Word-file in figure 2. You can take the profiles as in figure 1.

Regards,

Andrea

3 REPLIES 3
Highlighted
Level II

## Re: How do I create a model with a defined profile as a factor?

Hello Marjolein,

as far as I know, there is no preferred profile from the "statistical point of view". You have a categoric factor which is the profile. The question is: Which version does make more sense for the cell culture process and the purpose of your experiment?

Regards,
Andrea

Highlighted
Level I

## Re: How do I create a model with a defined profile as a factor?

Hi Andrea,

Can you explain a bit further how you would apply categorical variables to make the profile in time? I assumed that the levels for the categorical factors will be same value throughout process time, so its then not creating a profile over time.

kind regards, Marjolein

Highlighted
Level II

## Re: How do I create a model with a defined profile as a factor?

Hi Marjolein,

yes, the categorical factor wouldn't follow a profile, but it doesn't have to. Just create a categorical factor with three levels:

 Factor Name Role Values X Categorical L1 = profile 1 L2 = profile 2 L3 = profile 3

The profiles don't have to be the same, each can follow an unique time-program. The "mid-level" (profile 2) doesn't have to be the "center-point" as you showed in your Word-file in figure 2. You can take the profiles as in figure 1.

Regards,

Andrea

Article Labels

There are no labels assigned to this post.