topic #Screening DoE in Discussions

#Screening DoE

RevathiT — Thu, 08 Jun 2023 21:03:25 GMT

i have excipient A of 4 different grades, how Can I include all those 4 different grades in a Denitive Screening DOE?

Re: #Screening DoE

P_Bartell — Tue, 30 Mar 2021 17:07:15 GMT

The short answer is you can't. Definitive screening designs are not suited for 4 level factors. Your best bet, lacking any additional insight into the other factors, your experimental goals and objectives, your responses, etc. is to investigate optimal DOE tactics...these are supported in JMP in the Custom Design platform.

Re: #Screening DoE

statman — Wed, 31 Mar 2021 17:26:51 GMT

My initial reaction is why are you testing at 4 levels if you are doing screening? The objective of screening designs for the most part is to examine a large number of factors in an efficient number of treatments. This is done using the principles of scarcity, hierarchy and heredity of effects. A 4-level factor allows for estimation of effects of hierarchy beyond what screening designs are intended to do. Can you pick the extremes of the 4 levels (which grades do you think will be the most different?) and test that factor at 2-levels?