topic Re: Does any one have the script of bootstrap F2 which is used for the comparison of dissolution curves? in Discussions

Does any one have the script of bootstrap F2 which is used for the comparison of dissolution curves?

Parsakarthik1 — Fri, 09 Jun 2023 23:31:31 GMT

Bootstrap f2 is used for the comparison of dissolution curves in pharma industry. I am trying to figure out if any one has built a script for this?

martindemel — Tue, 14 Jul 2020 17:57:52 GMT

May not be a ready to use script, but a presentation shared in the community.

Or even better with video and examples

Piet_Hoogkamer — Wed, 05 Aug 2020 07:57:46 GMT

I would like to see such a script, we did not develop it yet. We typically run the bootstrap in Matlab but have it available in R as well.

You could think about calling the R or Matlab bootstrap routine from a JMP script.

However, it is not just about the bootstrap routine, it is also about selecting time points and being able to combine results from several batches.

Creating a script doing it all is quite a task.

David_Burnham — Wed, 05 Aug 2020 13:42:19 GMT

I wrote a script to do F2 calculations a few years ago. I'll rummage through my archives to see if I still have a working copy.

David_Burnham — Wed, 05 Aug 2020 15:13:48 GMT

sorry - turns out it did F2 calcs but didn't do bootstrap intervals.

Eitan — Tue, 26 Apr 2022 05:50:36 GMT

Can you please share the script for f2 calculation, and explain how to arrange the data table?

Thanks

Piet_Hoogkamer — Tue, 26 Apr 2022 18:34:31 GMT

Please find enclosed the script and an example dataset, which will illustrate how to organize the data.

You need to subset the dataset by medium, which will give you four datasets, one for each medium.

Select as grouping column either 'type' or 'batch':

- With 'type' a comparison is made between all 3 reference batches (merged) versus all 3 test batches (merged)

- With 'batch' a comparison is made between a single reference and a single test batch.

Piet_Hoogkamer — Tue, 26 Apr 2022 18:35:52 GMT

Please note that the script is for calculation of the f2 metric as is, no bootstrapping is performed.

Eitan — Wed, 27 Apr 2022 05:42:20 GMT

Thanks

I succeeded running the script, it is very helpful.

Do you have a script for bootstrapping of dissolution data?

Thanks so much for your support,

Eitan

Piet_Hoogkamer — Wed, 27 Apr 2022 09:57:12 GMT

This functionality will likely become available with JMP 17, see

Eitan — Wed, 27 Apr 2022 13:22:55 GMT

Great thanks